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Only two patients receiving doses of STI571 of 300 mg or more discontinued therapy prematurely.
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The frequencies of these reported adverse reactions were similar in Study 2, comparing 12 vs 36 months of GLEEVEC treatment (12 mo; 36 mo), except for decreased hemoglobin (72%; 80%), periorbital edema (59%; 74%), muscle spasms (31%; 49%), decreased white blood cell count (35%; 47%), pain (26%; 46%), peripheral edema (33%; 41%), rash (29%; 39%), arthralgia (9%; 17%), and myalgia (9%; 15%), which were higher among patients receiving 36 months of adjuvant treatment with GLEEVEC.
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Debido a la superioridad sobre imatinib en términos de respuesta citogenética completa y tasa de respuesta molecular importante, tanto dasatinib como nilotinib se usan mucho como tratamiento de primera línea en adultos con LMC.
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