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Thus far, biosimilars are coming in at modest discounts of 10 to 20 % of the brand price, though these reductions could enhance as more competitors come on line and give insurers and pharmacy profit managers more negotiating leverage. A countervailing development is that 27 states have handed legal guidelines limiting pharmacists' capability to substitute biosimilars for branded drugs even when the FDA has designated them as interchangeable. While these state laws differ in scope and restrictiveness, they cumulatively have the effect of increasing the price of biosimilar competitors.
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